Glia

Glial cells, commonly called '''neuroglia''' or simply '''glia''', are non- Neuron al cells that provide support and nutrition, maintain Homeostasis , form Myelin , and participate in signal transmission in the Nervous System . In the Human Brain , glia are estimated to outnumber neurons by as much as 50 to 1.

FUNCTION OF THE GLIAL CELL

Some glia function primarily as physical support for neurons. Others regulate the internal environment of the brain, especially the fluid surrounding neurons and their synapses, and provide nutrition to nerve cells. Glia have important developmental roles, guiding migration of neurons in early development, and producing molecules that modify the growth of Axon s and Dendrite s. Recent findings in the Hippocampus and Cerebellum have indicated that glia are also active participants in Synaptic Transmission , regulating clearance of neurotransmitter from the synaptic cleft, releasing factors such as ATP which modulate presynaptic function, and even releasing neurotransmitters themselves.

Traditionally glia had been thought to lack certain features of neurons. For example, glia were not believed to have Chemical Synapses , nor were they believed to generate Action Potential s or release Neurotransmitter s. They were considered to be the passive bystanders of neural transmission. However, recent studies disproved this. For example, Astrocyte s are crucial in clearance of Neurotransmitter within the Synaptic Cleft , which temporally and spatially restricts neurotransmission and limit the toxicity of certain neurotransmitters such as Glutamate . And at least in vitro astrocytes can release neurotransmitter glutamate in response to certain stimulation. Another unique type of glia, the Oligodendrocyte Precursor Cell s or OPCs, have very well defined and functional synapses from at least two major groups of neurons. The only notable differences between neurons and glia, by modern scrutiny, are the ability to generate Action Potential s and the polarity of neurons, namely the Axon s and Dendrite s which glia lack. It is inappropriate nowadays to consider glia as 'glue' in the nervous system as the name implies. They are also crucial in the development of nervous system and in processes such as Synaptic Plasticity and synaptogenesis.

TYPES OF GLIA

Microglia

Microglia are specialized Macrophage s capable of Phagocytosis that protect neurons of the CNS. Though not technically glia because they are derived from hemopoietic precursors rather than Ectodermal tissue, they are commonly categorized as such because of their supportive role to neurons. These cells, comprise approximately 15% of the total cells of the CNS. They are found in all regions of the brain and spinal cord. Microglial cells are small relative to macroglial cells, with changing shapes and oblong nuclei. They are mobile within the brain and multiply when the brain is damaged. In the healthy CNS, microglia processes constantly sample all aspects of their environment (neurons, macroglia and blood vessels).

Macroglia

Central nervous system

=Astrocytes

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The most abundant type of glial cell, Astrocyte s (also called ''astroglia'') have numerous projections that anchor neurons to their blood supply. They regulate the external Chemical environment of neurons by removing excess Ion s, notably Potassium , and recycling Neurotransmitter s released during Synaptic Transmission . The current theory suggests that astrocytes may be the predominant "building blocks" of the Blood-brain Barrier . Astrocytes may regulate vasoconstriction and vasodilation by producing substances such as Arachidonic Acid , whose metabolites are vasoactive.

Astrocytes signal each other using Calcium . The Gap Junction s (also known as electrical synapses) between astrocytes allow the messenger molecule IP3 to diffuse from one astrocyte to another. IP3 activates calcium channels on cellular organelles, releasing calcium into the cytoplasm. This calcium may stimulate the production of more IP3. The net effect is a calcium wave that propagates from cell to cell. Extracellular release of ATP , and consequent activation of Purinergic receptors on other astrocytes, may also mediate calcium waves in some cases.

There are generally two types of astrocytes, protoplasmic and fibrous, similar in function but distinct in morphology and distribution. Protoplasmic astrocytes have short, thick, highly branched processes and are typically found in gray matter. Fibrous astrocytes have long, thin, less branched processes and are more commonly found in white matter.

=Oligodendrocytes

Oligodendrocyte s are cells that coat axons in the Central Nervous System (CNS) with their cell membrane, called Myelin , producing the so-called Myelin Sheath . The myelin sheath provides Insulation to the axon that allows Electrical signals to propagate more efficiently.

=Ependymal cells

Ependymal Cell s, also named ''ependymocytes'', line the cavities of the CNS and beat their Cilia to help circulate the Cerebrospinal Fluid . They make up the "walls" which segment different zones.

=Radial glia

Radial glia cells arise from neuroepithelial cells after the onset of neurogenesis. Their differentiation abilities are more restricted compared to those of neuroepithelial cells. In the developing nervous system, radial glia function both as neuronal progenitors and as a scaffold upon which newborn neurons migrate. In the mature brain, the cerebellum and retina retain characteristic radial glial cells. In the cerebellum, these are Bergmann Glia , which regulate synaptic plasticity. In the retina, the radial Müller Cell is the principal glial cell, and participates in a bidirectional communication with neurons.

Peripheral nervous system

=Schwann cells

Similar in function to oligodendrocytes, Schwann Cell s provide myelination to axons in the Peripheral Nervous System (PNS). They also have Phagocytotic activity and clear cellular debris that allows for regrowth of PNS neurons.

=Satellite cells

Satellite Cell s are small cells that line the exterior surface of PNS neurons and help regulate the external chemical environment.

CAPACITY TO DIVIDE

A misconception about glia is that they retain the ability to undergo Mitosis in adulthood, while neurons cannot. The view is based on the general deficiency of the mature nervous system in replacing neurons after an insult or injury, such as a Stroke or trauma, while very often there is a profound proliferation of glia, or Gliosis near or at the site of damage. However, detailed studies found no evidence that 'mature' glia, such as astrocytes or Oligodendrocyte s, retain the ability of mitosis. Only the resident Oligodendrocyte Precursor Cell s seem to keep this ability after the nervous system matures. On the other hand, there are a few regions in the mature nervous system, such as the Dentate Gyrus of the Hippocampus and the Subventricular Zone , where generation of new neurons can be observed.

EMBRYOLOGICAL DEVELOPMENT

Most glia are derived from Ectodermal tissue of the developing Embryo , particularly the Neural Tube and Crest . The exception is Microglia , which are derived from hemopoietic stem cells. In the adult, microglia are largely a self-renewing population and are distinct from macrophages and monocytes which infiltrate the injured and diseased CNS.

In the central nervous system, glia develop from the ventricular zone of the neural tube. These glia include the oligodendrocytes, ependymal cells, and astrocytes. In the peripheral nervous system, glia derive from the neural crest. These PNS glia include Schwann cells in nerves and satellite cells in ganglia.

HISTORY

Glia were discovered in 1891 by the early Spanish neuroanatomist Santiago Ramón Y Cajal .

The brain contains about nine times more glial cells than neurons. Following its discovery in the 20th century, this fact underwent significant media distortion, emerging as the famous myth claiming that "we are using only 10% of our brain". The role of glial cells as managers of communications in the synapse gap, thus modifying learning pace, has been discovered only very recently ( 2004 ).

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