In
Medicine , is a state in which the blood
PH is low (under 7.35) due to increased production of
H+ by the body or the inability of the body to form
Bicarbonate (HCO
3-) in the
Kidney . Its causes are diverse, and its consequences can be serious, including
Coma and
Death . Together with
Respiratory Acidosis , it is one of the two general types of
Acidosis .
Symptoms are aspecific, and diagnosis can be difficult unless the patient presents with clear indications for
Arterial Blood Gas sampling. Symptoms may include
Chest Pain ,
Palpitations ,
Headache , altered mental status, decreased visual acuity,
Nausea ,
Vomiting ,
Abdominal Pain , altered appetite (either anorexia or excessive eating) and
Weight Loss (longer term), muscle weakness and bone pains. A slightly specific finding is when the patient reports rapid breathing, not due to shortness of breath but an unmotivated drive to hyperventilate.
Kussmaul Respiration is rare, but may indicate
Ketoacidosis .
Exteme acidosis leads to neurological and cardiac complications:
Physical Examination occasionally reveals signs of disease, but is otherwise normal.
Cranial Nerve abnormalitites are reported in
Ethylene Glycol poisoning, and
Retina l edema can be a sign of
Methanol (methyl alcohol) intoxication. Longstanding chronic metabolic acidosis leads to
Osteoporosis and can cause
Fracture s.
Arterial Blood Gas sampling is essential for the diagnosis. The pH is low (under 7.35) and the bicarbonate levels are decreased (<12 mmol/l). In
Respiratory Acidosis (low blood pH due to decreased clearance of
Carbon Dioxide by the
Lung s), the bicarbonate is elevated, due to increased conversion from H
2CO
3. An
ECG can be useful to anticipate cardiac complications.
Other tests that are relevant in this context are
Electrolyte s (including
Chloride ),
Glucose ,
Renal Function and a
Full Blood Count . Urinalysis can reveal acidity (
Salicylate poisoning) or alkalinity (renal tubular acidosis type I). In addition, it can show ketones in ketoacidosis.
To distinguish between the main types of metabolic acidosis, a clinical tool called the ''
Anion Gap '' is considered very useful. It is calculated by subtracting the chloride and bicarbonate levels from the sodium plus potassium levels.
Anion gap = (
) - ( [Cl- +[HCO
3-] )
As sodium and potassium are the main extracellular cations, and chloride and bicarbonate are the main anions, the result should reflect the remaining anions. Normally, this concentration is about 8-16 mmol/l. An elevated ''anion gap'' (i.e. > 16 mmol/l) can indicate particular types of metabolic acidosis, particularly certain poisons, lactate acidosis and ketoacidosis.
As the
Differential Diagnosis is narrowed down, certain other tests may be necessary, including toxicological screening and imaging of the kidneys.
The causes are best grouped by their influence on the ''
Anion Gap '':
- Lactic Acidosis
- Ketoacidosis
- Chronic Renal Failure (accumulation of Sulfate s, Phosphate s, Uric Acid )
- intoxication:
- --- Organic Acid s ( Salicylate s, Ethanol , Methanol , Formaldehyde , Ethylene Glycol , Paraldehyde , INH , Toluene )
- --- Sulfates , Metformin (Glucophage®)
- massive Rhabdomyolysis
It bears noting that the anion gap can be spuriously normal in sampling errors of the sodium level, e.g. in extreme
Hypertriglyceridemia . The anion gap can be increased due to relatively low levels of cations other than sodium and potassium (e.g. calcium or magnesium).
Metabolic acidosis is either due to increased generation of acid or an inability to generate sufficient bicarbonate. The body regulates the acidity of the blood by four buffering mechanisms.
- Blood buffering with bicarbonate. The enzyme Carbonic Anhydrase maintains the equilibrium between bicarbonate and H2CO3. This is, in turn, converted into carbon dioxide and Water .
- Intracellular buffering by absorption of hydrogen atoms by various molecules, including proteins, phosphates and carbonate in bone.
- Respiratory compensation: chemoreceptors sense a deranged acid-base system, and there is increased breathing.
- Renal compensation: finally the kidney produces and excretes Ammonium (NH4+) and monophosphate, generating bicarbonate in the process while clearing acid.
The elevated bicarbonate that distinguishes metabolic acidosis is therefore due to two separate processes: the buffer (from water and carbon dioxide) and additional renal generation. The buffer reactions are:
:H
+ + HCO
3- <--> H
2CO
3 <--> CO
2 + H
2O
The
Henderson-Hasselbalch Equation mathematically describes the relationship between blood pH and the components of the bicarbonate buffering system:
:pH=pKa + log
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:Using Henry's Law, we can say that
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:(PaCO2 is the pressure of CO2 in arterial blood)
:Adding the other normal values, we get
:pH = 6.1 + log (24/0.03x40)
: = 6.1 + 1.3
: = 7.4
A pH under 7.1 is an emergency, due to the risk of
Cardiac Arrhythmia s, and may warrant treatment with intravenous bicarbonate. Bicarbonate is given at 50-100 mmol at a time under scrupulous monitoring of the arterial blood gas readings. This intervention however, is not effective in case of
Lactic Acidosis .
If the acidosis is particularly severe and/or there may be intoxication, consultation with the
Nephrology team is considered useful, as
Dialysis may clear both the intoxication and the acidosis.
